Host: Rabbit

Target Protein: phospho-IRE1a (Ser 726)

IR: Immunogen Range:SF(p-S)RR

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 2081

Swiss Prot: O75460

Source: KLH conjugated synthesised phosphopeptide derived from human IRE1a around the phosphorylation site of Ser726 :SF(p-S)RR 

Purification: affinity purified by Protein A

Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background: Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis.