Host: Rabbit

Target Protein: Phospho-MKP1 (Ser318)

IR: Immunogen Range:HC(p-S)AE

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 1843

Swiss Prot: P28562

Source: KLH conjugated synthesised phosphopeptide derived from human MKP1 around the phosphorylation site of Ser318:HC(p-S)AE 

Purification: affinity purified by Protein A

Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background: The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues.