Host: Rabbit

Target Protein: CMYA2/PDE4DIP

IR: Immunogen Range:1501-1600/2365

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 9659

Swiss Prot: Q5VU43

Source: KLH conjugated synthetic peptide derived from human CMYA2/PDE4DIP:1501-1600/2365 

Purification: affinity purified by Protein A

Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background: May function as an anchor sequestering components of the cAMP-dependent pathway to Golgi and/or centrosomes. Myomegalin, is a 2,346 amino acid protein that contains one NBPF domain and localizes to the nucleus, cytoplasm, centrosome and Golgi apparatus. Expressed at high levels in fetal and adult heart and at lower levels in brain and placenta, myomegalin is thought to function as an anchoring protein that sequesters members of the cAMP-dependent pathway to the Golgi and to centrosomes, thereby mediating cAMP pathway dynamics. Translocations in the gene that encodes myomegalin are associated with myeloproliferative disorders (MBDs), a group of diseases caused by an overproduction of blood cells. Myomegalin exists as twelve isoforms due to alternative splicing events.