Host: Rabbit

Target Protein: BMP10

IR: Immunogen Range:331-424/424

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 27302

Swiss Prot: O95393

Source: KLH conjugated synthetic peptide derived from human BMP10:331-424/424 

Purification: affinity purified by Protein A

Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background: Bone morphogenic proteins (BMPs) are members of the TGF beta superfamily and are involved in the induction of cartilage and bone formation. BMP-10 (Bone morphogenetic protein 10) is a 424 amino acid secreted protein that exists as a disulfide-linked homodimer. Expressed specifically in heart tissue, BMP-10 functions to prevent the premature activation of p57 (a negative cell cycle regulator), thereby maintaining the proliferative activity of embryonic cardiomyocytes and playing a critical role in the formation of trabeculae within the developing heart. Additionally, BMP-10 inhibits the growth and migration of endothelial cells and functions as a ligand for ALK-1, a protein that is tightly linked to angiogenesis. This suggests that, in addition to its role in cardiomyocyte formation, BMP-10 participates in the formation of blood vessels in developing cardiac muscle.