Host: Rabbit

Target Protein: Integrin Alpha V + Beta 1

IR: Immunogen Range:

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 3685

Swiss Prot: P06756

Source: KLH conjugated synthetic Mixed peptides 915-948/1048(human Integrin αV)+ 21-70/798(human Integrin β1): 

Purification: affinity purified by Protein A

Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background: Integrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells.
Integrin alpha 5 belongs to the integrin alpha chain family. It contains seven FG-GAP repeats.
Integrin beta 1 belongs to the integrin beta chain family. It contains one VWFA domain.
Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein se
ems to enhance angiogenesis in Kaposi's sarcoma lesions.