Host: Rabbit

Target Protein: GlyR alpha 1 + 2 + 3

IR: Immunogen Range:101-200/449

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 2741

Swiss Prot: P23415

Source: KLH conjugated synthetic peptide derived from human GlyR alpha 1:101-200/449 

Purification: affinity purified by Protein A

Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background: Glycine receptors are members of the ligand-gated ion channel superfamily, which mediate fast inhibitory neurotransmission. The receptors are pentameric membrane proteins which form chloride channels. Binding of glycine to its receptor produces an increase in chloride conductance and membrane hyperpolarisation. Four genes encoding glycine receptor alpha subunits have been identified, together with a single beta polypeptide. Each subunit consists of a large extracellular N-terminal region, four transmembrane domains, and a large cytoplasmic domain.