Host: Rabbit
Target Protein: PAFR/PAF Receptor
IR: Immunogen Range:231-342/342
Clonality: Polyclonal
Isotype: IgG
Entrez Gene: 5724
Swiss Prot: P25105
Source: KLH conjugated synthetic peptide derived from human PAFR:231-342/342
Purification: affinity purified by Protein A
Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:
The PAF receptor binds platelet-activating factor (PAF) and is thought to mediate its action via a G protein that activates a phosphatidylinositol-calcium second messenger system. PAF is a chemotactic phospholipid mediator that possesses potent inflammatory, smooth-muscle contractile and hypotensive activity. It has been implicated as a mediator in diverse pathologic processes, such as allergy, asthma, septic shock, arterial thrombosis, and inflammatory processes.
The PAF receptor is induced by granulocyte macrophage colony-stimulating factor (GM-CSF), interleukin-5 and n-butyrate. A diverse range of compounds act as PAF receptor antagonists; these may be useful pharmacologically.
Size: 200ul
Concentration: 1mg/ml
Applications: WB=1:500-2000, IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500, Flow-Cyt=1µg/Test, ELISA=1:5000-10000
Cross Reactive Species: Human,Mouse,Rat (predicted: Chicken,Dog,Cow,Rabbit)
For research use only. Not intended for diagnostic or therapeutic use.