Host: Rabbit

Target Protein: phospho-heterochromatin protein 1 (pTyr41)

IR: Immunogen Range:VE(p-Y)YL

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: N/A

Swiss Prot: P05205

Source: KLH conjugated Synthesised phosphopeptide derived from human SLC7A11around the phosphorylation site of Ser481:VE(p-Y)YL 

Purification: affinity purified by Protein A

Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background: HP1 alpha is a component of heterochromatin. It recognizes and binds histone H3 tails methylated at Lys-9, leading to epigenetic repression. HP1 alpha may interact with lamin B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. HP1 proteins are relatively small proteins (~25 kDa) with a conserved amino-terminal chromo domain and a structurally related carboxy-terminal motif, the chromo shadow domain. Both domains of HP1 are required for binding to native chromatin in vivo, but they contribute differentially to binding in euchromatin and heterochromatin.