Host: Mouse

Target Protein: PMS2

IR: Immunogen Range:

Clonality: Monoclonal

Isotype: IgG

Entrez Gene: 5395

Swiss Prot: P54278

Source: KLH conjugated synthetic peptide derived from human PMS2: 

Purification: affinity purified by Protein A

Storage: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.151% sodium azide. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background: This gene is one of the PMS2 gene family members found in clusters on chromosome 7. The product of this gene is involved in DNA mismatch repair. It forms a heterodimer with MLH1 and this complex interacts with other complexes bound to mismatched bases. Mutations in this gene are associated with hereditary nonpolyposis colorectal cancer, Turcot syndrome, and are a cause of supratentorial primitive neuroectodermal tumors. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2008].