Host: Mouse
Target Protein: MET
IR: Immunogen Range:
Clonality: Monoclonal
Isotype: IgG
Entrez Gene: 4233
Swiss Prot: P08581
Source: KLH conjugated synthetic peptide derived from human MET:
Purification: affinity purified by Protein A
Storage: PBS with 0.09% (W/V) sodium azide Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background: This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers. [provided by RefSeq, May 2016]
Size: 100ul
Concentration: 1mg/ml
Applications: ICC=1:100
Cross Reactive Species: Human (predicted: Rat,Mouse)
For research use only. Not intended for diagnostic or therapeutic use.