Host: Mouse

Target Protein: HDAC3

IR: Immunogen Range:

Clonality:

Isotype: IgG2b, Kappa

Entrez Gene: 8841

Swiss Prot: O15379

Source: KLH conjugated synthetic peptide derived from human HDAC3: 

Purification: affinity purified by Protein G

Storage: PBS, Glycerol, BSA Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene. [provided by RefSeq, Jul 2008].