Host: Rabbit
Target Protein: FTO
IR: Immunogen Range:
Clonality:
Isotype: IgG
Entrez Gene: 79068
Swiss Prot: Q9C0B1
Source: KLH conjugated synthetic peptide derived from human FTO:
Purification: affinity purified by Protein A
Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background: Dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation. Has highest activity towards single-stranded RNA containing 3-methyluracil, followed by single-stranded DNA containing 3-methylthymine. Has low demethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine. Has no activity towards 1-methylguanine. Has no detectable activity towards double-stranded DNA. Requires molecular oxygen, alpha-ketoglutarate and iron. Contributes to the regulation of the global metabolic rate, energy expenditure and energy homeostasis. Contributes to the regulation of body size and body fat accumulation.
Size: 100ul
Concentration: 1mg/ml
Applications: WB=1:1000, IHC-P=1:100-500
Cross Reactive Species: Human
For research use only. Not intended for diagnostic or therapeutic use.