Host: Rat
Target Protein: mouse CD45R/PE-Cy7
IR: Immunogen Range:
Clonality: Monoclonal
Isotype: Rat IgG2a, k
Entrez Gene: 19264
Swiss Prot: P06800
Source: :
Purification: Affinity purified by Protein G
Storage: 0.01M PBS, 0.5%BSA, 0.03% Proclin300 Store at 2-8℃. Protect from light. Avoid freezing.
Background: CD45R, also known as B220, is an isoform of CD45. It is a member of the protein tyrosine phosphatase (PTP) family with a molecular weight of approximately 180-240 kD. CD45R is expressed on B cells (at all developmental stages from pro-B cells through mature B cells), activated B cells, and subsets of T and NK cells. CD45R (B220) is also expressed on a subset of abnormal T cells involved in the pathogenesis of systemic autoimmunity in MRL-Faslpr and MRL-Fasgld mice. It plays a critical role in TCR and BCR signaling. The primary ligands for CD45 are galectin-1, CD2, CD3, and CD4. CD45R is commonly used as a pan-B cell marker; however, CD19 may be more appropriate for B cell specificity.
Size: 50T
Concentration:
Applications:
Cross Reactive Species:
For research use only. Not intended for diagnostic or therapeutic use.