Host: Rabbit
Target Protein: CD244
IR: Immunogen Range:1-100/370
Clonality: Polyclonal
Isotype: IgG
Entrez Gene: 51744
Swiss Prot: Q9BZW8
Source:
KLH conjugated synthetic peptide derived from human NKR2B4:1-100/370
Purification: affinity purified by Protein A
Storage: 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Background: Natural killer (NK) cells are bone marrow-derived lymphocytes that can kill certain tumor cells and virally infected cells. There are multiple immunoglobulin superfamily (IgSF) receptor-ligand interactions that coordinate NK cell recognition of target cells and cytolytic function. The IgSF receptor NK 2B4 (CD244) is a ligand for CD48 that is expressed on the surface of all mouse and human NK cells and the subset of T cells that mediate NK-like killing. NK 2B4 is a cell surface glycoprotein of the immunoglobulin superfamily that is involved in the regulation of natural killer and T lymphocyte function. NK 2B4 binds the Src homology 2 domain-containing protein (SH2D1A) or signaling lymphocyte activation molecule (SLAM)-associated protein (SAP), which may function as regulators of NK 2B4-associated signal transduction pathways. NK 2B4 is expressed in human spleen, peripheral blood leukocytes, lymph node, bone marrow and fetal liver.
Size: 50ul
Concentration: 1mg/ml
Applications: WB=1:500-2000,ELISA=1:5000-10000
Cross Reactive Species: Human (predicted: Mouse,Rat)
For research use only. Not intended for diagnostic or therapeutic use.