Host: Rabbit

Target Protein: Presenilin 1 + 2

IR: Immunogen Range:321-430/467

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 5663

Swiss Prot: P49768

Source: KLH conjugated synthetic peptide derived from human Presenilin-1 NTF subunit:321-430/467 

Purification: affinity purified by Protein A

Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background: Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP.