Host: Rabbit
Target Protein: Presenilin 1 + 2
IR: Immunogen Range:321-430/467
Clonality: Polyclonal
Isotype: IgG
Entrez Gene: 5663
Swiss Prot: P49768
Source: KLH conjugated synthetic peptide derived from human Presenilin-1 NTF subunit:321-430/467
Purification: affinity purified by Protein A
Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background: Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP.
Size: 50ul
Concentration: 1mg/ml
Applications: WB=1:500-2000,IHC-P=1:100-500,IHC-F=1:100-500,ICC/IF=1:100,IF=1:100-500,ELISA=1:5000-10000
Cross Reactive Species: Human,Mouse,Rat (predicted: Chicken)
For research use only. Not intended for diagnostic or therapeutic use.