Host: Mouse

Target Protein: NAPSIN A

IR: Immunogen Range:

Clonality: Monoclonal

Isotype: IgG1/kappa

Entrez Gene: 16541

Swiss Prot: O09043

Source: KLH conjugated synthetic peptide derived from mouse NAPSIN A: 

Purification: affinity purified by Protein A

Storage: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background: Napsin A is an aspartic proteinase that belongs to the peptidase A1 family and plays a role in pneumocyte surfactant processing. It is a 420-amino acid polypeptide consisting of a 24-residue signal peptide, a 40-amino acid propart, the mature enzyme of 336 amino acids, and a C-terminal extension of 18 residues. The mature Napsin A protein contains 3 predicted disulfide bonds, 3 potential N-linked oligosaccharide attachment sites, an RGD motif, a recognition motif for integrin binding, in the C terminus, immediately before a 4-amino acid insert that is unique to aspartic proteinases. Highest levels of Napsin A have been detected in adult lung (type II pneumocytes), fetal lung, and kidney tissues. Napsin A is also expressed at lower levels in adult spleen and at very low levels in peripheral blood leukocytes. Human napsin A shares 72.6% sequence identity with the mouse homolog.