Host: Rabbit

Target Protein: Phospho-cdc25A (Ser76)

IR: Immunogen Range:MG(p-S)SE

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 993

Swiss Prot: P30304

Source: KLH conjugated synthesised phosphopeptide derived from human cdc25A around the phosphorylation site of Ser76:MG(p-S)SE 

Purification: affinity purified by Protein A

Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background: CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]