Host: Rabbit

Target Protein: PRNP

IR: Immunogen Range:23-120/253

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 5621

Swiss Prot: P04156

Source: KLH conjugated synthetic peptide derived from human PRNP:23-120/253 

Purification: affinity purified by Protein A

Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Background: The function of PrP is still under debate. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis (By similarity). Isoform 2 may act as a growth suppressor by arresting the cell cycle at the G0/G1 phase. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro).