Host: Rabbit

Target Protein: Insig2 Rabbit pAb

IR: Immunogen Range:65-160/225

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 51141

Swiss Prot: Q9Y5U4

Source: KLH conjugated synthetic peptide derived from human Insig2:65-160/225 

Purification: affinity purified by Protein A

Storage: 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

Background: Insig2 is highly similar to the protein product encoded by gene Insig1. Both Insig1 protein and Insig2 protein are endoplasmic reticulum proteins that block the processing of sterol regulatory element binding proteins (SREBPs) by binding to SREBP cleavage-activating protein (SCAP), and thus prevent SCAP from escorting SREBPs to the Golgi.