Host: Mouse
Target Protein: Irgm1
IR: Immunogen Range:
Clonality: Monoclonal
Isotype: IgM
Entrez Gene: 15944
Swiss Prot: Q60766
Source: Recombinant Mouse Irgm1 (His-tagged). :
Purification: affinity purified by Protein G
Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background: IRGM belongs to a family of interferon-gamma inducible GTPases, belonging to the GTPase superfamily, and are selectively induced by IFN-gamma or bacterial lipopolysaccharide (LPS) stimulation. IRGM is primarily expressed in all cells derived from B-cell lineages, and is highly expressed in macrophages following IFN-gamma stimulation. IRGM has been shown to be required for host defences against a broad range of intracellular pathogens. Specifically, IRGM deficient mice show defects with intracellular microbial killing, phagosome maturation and autophagy. More recently IRGM has been shown to inhibit baseline hematopoietic proliferation and is required for a normal hematopoietic stem cell response to chemical and infectious stimuli.
Size: 100ul
Concentration: 1mg/ml
Applications: WB=1:500-1000
Cross Reactive Species: Mouse
For research use only. Not intended for diagnostic or therapeutic use.