Host: Rabbit
Target Protein: CRTAM
IR: Immunogen Range:31-130/393
Clonality: Polyclonal
Isotype: IgG
Entrez Gene: 56253
Swiss Prot: O95727
Source:
KLH conjugated synthetic peptide derived from human CRTAM:31-130/393
Purification: affinity purified by Protein A
Storage: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background: CRTAM, (class-I MHC-restricted T-cell associated molecule), is an immunoglobulin-superfamily transmembrane protein and a new member of the nectin-like (Necls) family. In the immune system, CRTAM expression has been shown to be restricted to activated class-I MHC-restricted T cells, including NKT and CD8 T cells. CRTAM interacts with CADM1 and promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro, as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. Nectin-like (Necl) molecule 2, has been identified as a ligand of CRTAM. Necl2/CRTAM molecular pair could regulate a large panel of cell/cell interactions both within and outside of the immune system.
Size: 100ul
Concentration: 1mg/ml
Applications: ICC/IF=1:100-500,ELISA=1:5000-10000
Cross Reactive Species: Human (predicted: Mouse,Rat,Rabbit,Pig)
For research use only. Not intended for diagnostic or therapeutic use.