Host: Mouse
Target Protein: human CD25
IR: Immunogen Range:
Clonality: Monoclonal
Isotype: Mouse IgG2a, k
Entrez Gene: 3559
Swiss Prot: P01589
Source: KLH conjugated synthetic peptide derived from human CD25:
Purification: Affinity purified by Protein G
Storage: 0.01M TBS(pH=7.4) Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Background: The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency. Patients with severe Coronavirus Disease 2019 (COVID-19), the disease caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), have significantly elevated levels of IL2R in their plasma. Similarly, serum IL-2R levels are found to be elevated in patients with different types of carcinomas. Certain IL2RA and IL2RB gene polymorphisms have been associated with lung cancer risk. [provided by RefSeq, Jul 2020]
Size: 100ug
Concentration: 1mg/ml
Applications: Flow-Cyt=1ug/Test
Cross Reactive Species: Human
For research use only. Not intended for diagnostic or therapeutic use.